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Nanoconcepts and Simulations

Nanoconcepts represent self-contained instructional materials focusing on the key ideas in nanoscale science and engineering (NSE) and their applications. Each Nanoconcept contains a general user introduction, main concept, notes, images and/or simulations. A usage guide and connections to general science concepts is also provided to aid integration into the classroom.

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Insights in Nanomedicine: Fighting Cancer with Gold Nanoshells

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References

[1] The History of Gold from the National Mining Association, 101 Constitution Avenue, NW, Suite 500 East Washington, DC 20001.

[2] [2a] C. Loo, L. Hirsch, M. -H. Lee, E. Chang, J. West, N. Halas, and R. Drezek, "Gold nanoshell bioconjugates for molecular imaging in living cells," Optics Letters 30, 1012-1014 (2005).

[3] [3a] AuroLase™ Cancer Therapy. Nanospectra Biosciences, Inc. http://www.nanospectra.com/Aurolase.htm.

[4] [4a] W. M. Robertson, Surface Plasmon Research Page. 2004. Middle Tennessee State University.

[5] D. K. Roper, W. Ahn, M. Hoepfner, "Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold Nanoparticles," J. Phys. Chem. C 111 (9), 3636-3641 (2007).

[6] [6a] [6b] H. Wang, G. P. Goodrich, F. Tam, C. Oubre, P. Norlander, N. J. Halas, "Controlled Texturing Modifies the Surface Topography and Plasmonic Properties of Au Nanoshells." 2005. J. Phys. Chem. B, Vol. 09, No. 22.

[7] Fontana, E.; Thickness of Optimization of Metal Films for the Development of Surface-Plasmon-Based Sensors for NonAbsorbing Media. 2006. Applied Optics, Vol. 45, Issue 29, 7632-7642.

[8] Fields, S.; Gold Probes Could Reveal Cancer in Your Body. 2006. Live Science http://www.livescience.com/health/060113_gold_nanobars.html

[9] Public Health Statement for Silver. 1990. Agency for Toxic Substances and Disease Registry

[10] Alchemical History of Colloidal Gold. 2007. Crucible Catalog http://www.crucible.org/gold_colloids.htm.

[11] [11a] Pham, T.; Jackson, J.B.; Halas, N.J.; Lee, T.R.; Preparation and Characterization of Gold Nanoshells Coated with Self-Assembled Monolayers. 2002. Langmuir vol. 18, 4915-4920.

[12] [12a] Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; et al; Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. 2003. Proc Natl Acad Sci U S A, v.100(23); Nov 11, 2003.

[13] [13a] Wang, H.; Daniel, B.W; Norlander, P.; Halas, N.J.; Plasmonic Nanostructures: Artificial Molecules. Acc. Chem. Res 2007, 40, 53-60.

[14] Loo, C.; Lin, A.; Hirsch, L.; Lee, M.; Barton, J.; Halas, N.; West, J.; Drezek, R.; Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer. 2004. Technology in Cancer Research & Treatment, volume 3, number 1.

[15] Loo, C.; Lowery, A.; Halas, N.; West, J.; Drezek, R.; Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy. 2005. Nano Letters Vol. 5, No. 4, 709-711.

[16] [16a] [16b] [16c] Sershen, S.R.; Mensing, G.A.; Ng, M.; Halas, N.J.; Beebe, D.J.; West, J.L.; Independent Optical Control of Microfluidic Valves formed from Optomechanically Responsive Nanocomposite Hydrogels. Adv. Mater. 2005. 17,1366-1368.

[17] O'Neal, D.P.; Hirsch, L.R.; Halas, N.J.; Payne, J.D.; West, J.L.; Photo-thermal Tumor Ablation in Mice Using Near Infrared-absorbing Nanoparticles. 2004. Cancer Letters 209, 171-176.

[18] Dictionary of Cancer Terms: EGFR. National Cancer Institute. http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=44397.

[19] Huang, X.; Determination of the Minimum Temperature Required for Selective Photothermal Destruction of Cancer Cells with the Use of Immunotargeted Gold Nanoparticles. 2006. American Society for Photobiology, Mar/Apr 2006.

[20] [20a] [20b]Kelleher, K.; Engineers Light Up Cancer Research. 2003. Popular Science, October, 34-35 http://www.ece.rice.edu/~halas/articles/PopSci03.pdf.

[21] [21a] Lin, A.W.H.; Lewinski, N.A.; West, J.L.; Halas, N.J.; Drezek, R.A.; Optically Tunable Nanoparticle Contrast Agents for Early Cancer Detection: Model-Based Analysis of Gold Nanoshells. 2005. Journal of Biomedical Optics, Vol. 10(6), 064035 1-10.

[22] Riha, D.; Optical Coherence Tomography. 2005. Research Imaging Center. http://biad02.uthscsa.edu/personalpages/lancaste/DI2_Projects_2004/DR_Project.pdf.

[23] Boyer, D.; Tamarat, P.; Maali, A.; Lounis, B.; Orrit, M.; Photothermal Imaging of Nanometer-Sized Metal Particles Among Scatterers. 2002. Science Mag, 297, 1160-1163.

[24] The "water-window" refers to the wavelengths of the electromagnetic spectra that light passes through tissue most unobstructed. The "water-window" ranges from light wavelengths of 800 nm to 1200 nm and tissue exhibits small absorption and scattering of light. It is called the "water-window" because tissue is nearly 90% water and this is the region which light passes through water the easiest.

[25] [25a] Talley, C.E.; Jackson, J.B.; Oubre, C.; Grady, N.K.; Hollars, C.W.; Lane, S.M. Huser, T.R.; Norlander, P.; Halas, N.J.; Surface-Enhanced Raman Scattering from Individual Au Nanoparticles and Nanoparticle Dimer Substrates. 2005. Nano Letters, Vol. 5, No. 8, 1569-1574.

[26] Brongersma, M.L.; Nanoshells: Gifts in a Gold Wrapper. 2003. Nature Materials, May, 296-297 http://www.ece.rice.edu/~halas/articles/nmat891.pdf.

[27] Richardson, H.H.; Hickman, Z.N.; Govorov A.O.; Thomas, A.C.; Zhang, W.; Kordesch, M.E.; Thermooptical Properties of Gold Nanoparticles Embedded in Ice: Characterization of Heat Generation and Melting. 2006. Nano Letters, Vol. 6, No. 4, 783-788.

[28] Wang, H.; Goodrich, G.P.; Tam, F.; Oubre, C.; Nordlander, P.; Halas, N.J.; Controlled Texturing Modifies the Surface Topography and Plasmonic Properties of Au Nanoshells. 2005. Journal of Physical Chemistry Letters, Vol. 109, 11083-11087.

[29] Torabi, M.; Aquino, S.L.; Harisinghani, M.G.; Current Concepts in Lymph Node Imaging. 2004. J Nucl Med, Vol. 45, 1509-1518.

[30] Kaiser, M.; Heintz, J.; Kandela, I.; Albrecht, R.; tumor Cell Death Induced by Membrane Melting via Immunotargeted, Inductively Heated Core/Shell Nanoparticles. 2007. Microscopy Microanalysis, Vol. 13, Suppl. 2.

[31] Sershen, S.R.; Westcott, S.L.; Halas, N.J.; West, J.L.; Temperature-Sensitive Polymer-Nanoshell Composites for Photothermally Modulated Drug Delivery. 2000. J. Biomed. Mater. Res. 51(3).

[32] Gobin, A.M.; O'Neal, P.; Watkins, D.M.; Halas, N.J.; Drezek R.A.; West, J.L.; Near Infrared Laser-Tissue Welding Using Nanoshells as an Exogenous Absorber. 2005. Lasers in Surgery and Medicine, Vol. 37, 123-129.

[33] Elghanian, R.; Storhoff, J.J.; Mucic, R.C.; Letsinger, R.L.; Mirkin, C.A.; Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles. 1997. Science 277, 1078-81.

[34] Kumar, S.; Sokolov, K.; Richards-Kortum, R.; In-Vivo Optical Detection of Intracellular Cancer Biomarkers using Gold Nanoaprticles. 2006. Nanobiophotonics and Biomedical Applications III. SPIE Vol. 6095, 609504- 1-10.

 

 

 

Author(s):
J.R. Ireland1
J. McMath1
J. Ramsley1
D. Stehura1
M. Sukharev1
T. Seideman1
U. Ravaioli2
H.S. Hahm2
R. D. Braatz2
L.M. Goh2
E. Rusli2
J.A. Washington2
J. Pazmino2
S. Im2
M. Fujiwara2


Institution:
1Northwestern University, IL, USA, 2University of Illinois at Urbana-Champaign, IL, USA