DNA and Models

ABSTRACT:
The lesson includes concepts related to small scale and self-assembly.
The current lesson is focused on the design of single-strand DNA to detect
viruses. This topic appears well-suited for the purpose, since middle-school students are familiar with
viruses and understand the need to detect them. The design approach was chosen as a vehicle for instruction-as
opposed to didactic presentation or procedural training-with the consideration that the active construction
of meaning involving first-hand experience with representations would support learning about these concepts.
The learning goals of the current study include (a) that a single strand of DNA can catch another
(viral) single strand, (b) that each strand is composed of nucleotides containing one of four bases:
Adenine (A), Thymine (T), Cytosine (C), or Guanine (G), (c) that these nucleotides will selectively attract
and bond with other nucleotides (base-pairings: A with T, C with G), and (d) that this process is used
to 'detect' viruses and happens at nanoscale.
EVALUATION METHODS:
Pre and post tests, in class materials and activities.
Lessson Plan:
Presentations:
Additional Materials:
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Authors:
Brenda A López Silva,
Marco Bernasconi,
John Bell,
Raedy Ping,
Tom Moher
Institutions:
University of Illinois at
Chicago, IL USA
Grade level:
6-9
Subject:
Chemistry
Time Allocation:
Six days of an hour to 90 minutes each, including two for pre-post assessment.
For Classroom:
The content covers basic concepts that can be discussed more in depth, some of the suggested activities
can be modified based on teacher's preference. The simulation settings require a more advance level of
expertise on the teachers end, but the simulation can be run on a desktop environment instead of the
downward ceiling projection.
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